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Immune Hemolytic Anemias (Online CE Course)

(based on 710 customer ratings)

Author: Erin Tretter, MBA, MT(ASCP)
Reviewer: Kathy W. Jones, MS, MLS(ASCP)CM

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-013-18, approved through 6/30/2020
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Blood Banking / Immunohematology): 2 hour(s)
Course number 20-659548, approved through 9/1/2020

Objectives

  • Compare the different types of immune hemolytic anemias.
  • Identify and investigate potential serologic discrepancies caused by autoimmune and drug-induced hemolytic anemias.
  • Differentiate the four mechanisms involved in drug-induced hemolytic anemias.
  • List medications that may be associated with drug-induced hemolytic anemia.

Customer Ratings

(based on 710 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Immune Hemolytic Anemias
  • Alloimmune Hemolytic Anemia
  • Autoimmune Hemolytic Anemias
  • Drug-Induced Hemolytic Anemia
      • Drug-Induced Immune Hemolytic Anemia Introduction
      • Mechanisms
      • Drug Adsorption Mechanism
      • Immune Complex Mechanism
      • Membrane Modification (Non-Immune Adsorption of Proteins)
      • Induction of Autoimmunity
      • Treatment of Drug-Induced Immune Hemolytic Anemia
      • Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia
      • Which mechanism of drug-induced red cell destruction closely mimics the serologic presentation of warm autoimmune hemolytic anemia (WAIHA)?
      • Which mechanism of drug-induced hemolytic anemia involves the formation of drug-antibody combinations that bind non-specifically to RBC membranes and ...
      • Penicillin is one of the medications that may be responsible for the immune-complex mechanism of drug-induced hemolytic anemia.
  • Case Study
      • Case Study OneA 50-year-old female patient with systemic lupus erythematosus (SLE) is admitted to the hospital with evidence of hemolysis, including d...
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continuedTo determine the appropriate adsorption technique to use, an accurate transfusion history must be obtained. In this case the ...
      • Case Study One, continued The results of the autoadsorbed serum tested with a set of antibody screen cells are shown on the right. What does the patte...
      • Case Study One Conclusion
  • Case Study
      • Case Study Two
      • Case Study Two, continued
      • Case Study Two, continuedA DAT is ordered on the patient along with an antibody screen. The DAT is positive and the antibody screen is negative. Eluti...
      • Case Study Two, Conclusion
  • References

Additional Information

Author information: Erin Tretter, MBA, MT(ASCP), is currently the Rapid Response Laboratory Supervisor at Paoli Hospital. Erin received her Masters in Business Administration from Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor’s Society. She received her BS in Medical Technology from California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology and Chemistry. Erin is currently the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s Hospital for Children and has 7 years experience teaching immunohematology concepts and laboratory procedures to laboratory science students. She has also taught Blood Bank in the Clinical Laboratory Technician program at the Community College of Philadelphia.
Reviewer information: Kathy W. Jones, MS, MLS(ASCP)CM is currently an Associate Professor in the Medical Laboratory Science Program at Auburn University Montgomery where she is responsible for the program courses in Clinical Hematology and Clinical Immunology. She holds a BS degree in Biology as well as a Master’s degree in Adult Education from Troy University. She received her Medical Laboratory Science certificate from St. Margaret’s Hospital School of Medical Technology and will celebrate her 40th year in Laboratory Science this year. Before she became a full-time educator she served in various roles in the clinical laboratory which included five years as a Hematology Supervisor.
 

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Keywords

These are the most common topics and keywords covered in Immune Hemolytic Anemias:

reticulocyte amplitude adsorb erythrocyte davis antigen-negative incubation hematocrit plasma disease medication contains polyspecific adsorbed drug-adsorption hemolytic serum harvested drug-antidrug donath-landsteiner saunders biphasic treatment titer agglutination anemia immunoglobulins info demonstrable warmer warm-reactive immune-mediated allogeneic blood specificity globulin clinical red blood cells antigen phenotypes blood bank philadelphia procedures serological anti-i anemias autocontrol autoimmunity alloantibodies mononucleosis alloantibody newborn sensitizes adsorptions non-reactive hemagglutinin button non-self cells antigens drug cold-reactive autoadsorptions hemolysis anti-igg body waiha adsorption identification fails drug-treated harmening intravascular eluate saline diagnosis vitro drug-induced antiglobulin autoadsorbed monospecific rbcs serologic reagents specificities rudmann bethesda discrepancies anti-p modern transfused pathologic immune antigen-antibody donor proceeding controls indistinguishable hemolysin elution red blood cell antihuman autoantibody transfusion hemoglobin symptoms erythematosus autologous jaundice bilirubin intravenous infectious autoimmune considerations antibodies penicillin non-immune anti-c3 aiha transfuse polychromatophilic hemoglobinuria crossmatches autoadsorption medicine reactive laboratory phenotype infection high-dose blood banking antibody lupus paroxysmal non-specifically hemoglobinemia autoantibodies transfusions
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case1_autoadsorbedserum


Donath Landsteiner Test


Protein Adsorption


Warm autoimmune.JPG