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Immune Hemolytic Anemias (Online CE Course)

(based on 512 customer ratings)

Author: Erin Tretter, MBA, MT(ASCP)
Reviewer: Christine Christopher, MT(ASCP)SBB

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-013-16, approved through 3/31/2018
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Blood Banking / Immunohematology): 2 hour(s)
Course number 20-547769, approved through 9/1/2018

Objectives

  • Compare the different types of immune hemolytic anemias.
  • Identify and investigate potential serologic discrepancies caused by autoimmune and drug-induced hemolytic anemias.
  • Differentiate the four mechanisms involved in drug-induced hemolytic anemias.
  • List medications that may be associated with drug-induced hemolytic anemia.

Customer Ratings

(based on 512 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Immune Hemolytic Anemias
  • Alloimmune Hemolytic Anemia
  • Autoimmune Hemolytic Anemias
  • Drug-Induced Hemolytic Anemia
      • Drug-Induced Immune Hemolytic Anemia Introduction
      • Mechanisms
      • Drug Adsorption Mechanism
      • Immune Complex Mechanism
      • Non-Immune Adsorption of Proteins
      • Induction of Autoimmunity
      • Treatment of Drug-Induced Immune Hemolytic Anemia
      • Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia
      • Which mechanism of drug-induced red cell destruction closely mimics the serologic presentation of warm autoimmune hemolytic anemia (WAIHA)?
      • Which mechanism of drug-induced hemolytic anemia involves the formation of drug-antibody combinations that bind non-specifically to RBC membranes and ...
      • Penicillin is one of the medications that may be responsible for the immune-complex mechanism of drug-induced hemolytic anemia.
  • Case Study
      • Case Study OneA 50-year-old female patient with systemic lupus erythematosus (SLE) is admitted to the hospital with evidence of hemolysis, including d...
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continuedTo determine the appropriate adsorption technique to use, an accurate transfusion history must be obtained. In this case the ...
      • Case Study One, continued The results of the autoadsorbed serum tested with a set of antibody screen cells are shown on the right. What does the patte...
      • Case Study One Conclusion
  • Case Study
      • Case Study Two
      • Case Study Two, continued
      • Case Study Two, continuedA DAT is ordered on the patient along with an antibody screen. The DAT is positive and the antibody screen is negative. Eluti...
      • Case Study Two, Conclusion
  • References

Additional Information

Author information: Erin Tretter, MBA, MT(ASCP), is currently the Rapid Response Laboratory Supervisor at Paoli Hospital. Erin received her Masters in Business Administration from Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor’s Society. She received her BS in Medical Technology from California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology and Chemistry. Erin is currently the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s Hospital for Children and has 7 years experience teaching immunohematology concepts and laboratory procedures to laboratory science students. She has also taught Blood Bank in the Clinical Laboratory Technician program at the Community College of Philadelphia.
Reviewer information: Christine Christopher, MT(ASCP)SBB has over 25 years of experience as a Medical Technologist. She holds a Bachelors degree in Medical Technology from Northern Illinois University and Certification as a Specialist in Blood Bank. She has been employed by Central Dupage Hospital in Winfield, IL as a Medical Technologist and by the College of American Pathologists as an Inspection Specialist in the Laboratory Accreditation Program and as a Technical Assessor for the CAP 15189 ISO program.
 

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Donath Landsteiner Test
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Keywords

These are the most common topics and keywords covered in Immune Hemolytic Anemias:

anemia paroxysmal drug-adsorption transfusion antigen-negative phenotypes antigen-antibody specificities hemoglobinemia blood banking reagents sensitizes philadelphia titer pathologic anti-i adsorb drug transfusions cells newborn antibodies jaundice proceeding vitro autocontrol non-specifically specificity autoadsorption autoantibodies demonstrable hemolysis hematocrit reticulocyte rbcs immune intravenous penicillin harvested reactive anti-igg saunders antiglobulin antihuman autologous eluate anti-c3 phenotype immunoglobulins serologic medicine disease adsorptions contains button non-self waiha warmer indistinguishable polychromatophilic adsorption erythrocyte rudmann incubation symptoms biphasic elution hemoglobinuria transfused autoimmunity autoantibody amplitude antigens polyspecific hemoglobin warm-reactive identification agglutination drug-antidrug red blood cell alloantibodies infection hemagglutinin autoadsorptions donor anemias blood bank hemolysin clinical donath-landsteiner intravascular blood diagnosis laboratory harmening hemolytic aiha serum alloantibody autoadsorbed saline discrepancies antigen adsorbed mononucleosis bilirubin high-dose treatment non-reactive medication transfuse infectious controls globulin drug-induced procedures red blood cells anti-p erythematosus drug-treated plasma info modern davis bethesda antibody fails considerations body allogeneic monospecific non-immune immune-mediated serological crossmatches autoimmune cold-reactive lupus
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barb-polychro-arrows


case1_autoadsorbedserum


Donath Landsteiner Test


Protein Adsorption


Warm autoimmune.JPG