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Immune Hemolytic Anemias (Online CE Course)

(based on 596 customer ratings)

Author: Erin Tretter, MBA, MT(ASCP)
Reviewer: Kathy W. Jones, MS, MLS(ASCP)CM

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Continuing Education Credits

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Blood Banking / Immunohematology): 2 hour(s)
Course number 20-547769, approved through 9/1/2018

Objectives

  • Compare the different types of immune hemolytic anemias.
  • Identify and investigate potential serologic discrepancies caused by autoimmune and drug-induced hemolytic anemias.
  • Differentiate the four mechanisms involved in drug-induced hemolytic anemias.
  • List medications that may be associated with drug-induced hemolytic anemia.

Customer Ratings

(based on 596 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Immune Hemolytic Anemias
  • Alloimmune Hemolytic Anemia
      • Alloimmune Hemolytic Anemia
  • Autoimmune Hemolytic Anemias
  • Drug-Induced Hemolytic Anemia
      • Drug-Induced Immune Hemolytic Anemia Introduction
      • Mechanisms
      • Drug Adsorption Mechanism
      • Immune Complex Mechanism
      • Membrane Modification (Non-Immune Adsorption of Proteins)
      • Induction of Autoimmunity
      • Treatment of Drug-Induced Immune Hemolytic Anemia
      • Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia
      • Which mechanism of drug-induced red cell destruction closely mimics the serologic presentation of warm autoimmune hemolytic anemia (WAIHA)?
      • Which mechanism of drug-induced hemolytic anemia involves the formation of drug-antibody combinations that bind non-specifically to RBC membranes and ...
      • Penicillin is one of the medications that may be responsible for the immune-complex mechanism of drug-induced hemolytic anemia.
  • Case Study
      • Case Study OneA 50-year-old female patient with systemic lupus erythematosus (SLE) is admitted to the hospital with evidence of hemolysis, including d...
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continuedTo determine the appropriate adsorption technique to use, an accurate transfusion history must be obtained. In this case the ...
      • Case Study One, continued The results of the autoadsorbed serum tested with a set of antibody screen cells are shown on the right. What does the patte...
      • Case Study One Conclusion
  • Case Study
      • Case Study Two
      • Case Study Two, continued
      • Case Study Two, continuedA DAT is ordered on the patient along with an antibody screen. The DAT is positive and the antibody screen is negative. Eluti...
      • Case Study Two, Conclusion
  • References
      • References

Additional Information

Author information: Erin Tretter, MBA, MT(ASCP), is currently the Rapid Response Laboratory Supervisor at Paoli Hospital. Erin received her Masters in Business Administration from Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor’s Society. She received her BS in Medical Technology from California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology and Chemistry. Erin is currently the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s Hospital for Children and has 7 years experience teaching immunohematology concepts and laboratory procedures to laboratory science students. She has also taught Blood Bank in the Clinical Laboratory Technician program at the Community College of Philadelphia.
Reviewer information: Kathy W. Jones, MS, MLS(ASCP)CM is currently an Associate Professor in the Medical Laboratory Science Program at Auburn University Montgomery where she is responsible for the program courses in Clinical Hematology and Clinical Immunology. She holds a BS degree in Biology as well as a Master’s degree in Adult Education from Troy University. She received her Medical Laboratory Science certificate from St. Margaret’s Hospital School of Medical Technology and will celebrate her 40th year in Laboratory Science this year. Before she became a full-time educator she served in various roles in the clinical laboratory which included five years as a Hematology Supervisor.
 

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Keywords

These are the most common topics and keywords covered in Immune Hemolytic Anemias:

non-immune serologic drug-adsorption alloantibodies drug-antidrug controls bethesda immunoglobulins contains transfusions autoimmunity harmening infection adsorptions crossmatches adsorbed reactive antibodies autoadsorption immune eluate waiha warm-reactive hemagglutinin drug-treated paroxysmal anti-igg warmer hemolysis pathologic info agglutination incubation specificity aiha phenotype anti-c3 newborn adsorption hemoglobinemia blood body procedures adsorb polychromatophilic indistinguishable serological hemolysin phenotypes discrepancies non-self diagnosis donath-landsteiner philadelphia transfusion non-specifically immune-mediated antigen-antibody alloantibody autoantibodies amplitude antihuman intravenous cold-reactive rudmann mononucleosis antigens globulin antibody saunders harvested autologous hemoglobinuria blood bank antigen-negative transfuse hematocrit transfused symptoms sensitizes laboratory autoimmune elution hemoglobin specificities anti-i proceeding vitro medication autoantibody anemia anemias fails red blood cell allogeneic hemolytic infectious button drug treatment polyspecific jaundice serum plasma non-reactive disease saline anti-p modern reticulocyte drug-induced erythematosus medicine bilirubin autocontrol penicillin red blood cells autoadsorbed antiglobulin demonstrable titer rbcs autoadsorptions biphasic reagents clinical identification lupus monospecific intravascular considerations davis blood banking donor high-dose antigen cells erythrocyte
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case1_autoadsorbedserum


Donath Landsteiner Test


Protein Adsorption


Warm autoimmune.JPG