Course Outline
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- Immune Hemolytic Anemias
- Alloimmune Hemolytic Anemia
- Autoimmune Hemolytic Anemia
- Autoimmune Hemolytic Anemia (AIHA) Introduction
- Symptoms of Autoimmune Hemolytic Anemia
- Testing for Autoantibodies
- Possible Serological and Laboratory Presentations
- True or False: A direct antiglobulin test (DAT) is usually negative in cases of autoimmune hemolytic anemia.
- Symptoms associated with autoimmune hemolytic anemias can include:
- Cold Autoimmune Hemolytic Anemia
- Warm Autoimmune Hemolytic Anemia
- Warm Autoimmune Hemolytic Anemia (WAIHA)
- Serological Characteristics in WAIHA
- WAIHA Investigation: Serological Findings Following Elution
- Possible Scenarios When Transfusions are Needed in the Presence of WAIHA
- Detection and Identification of an Alloantibody in the Presence of a Warm-Reactive Autoantibody
- Autologous Adsorption (Autoadsorption)
- Allogeneic Adsorption
- Transfusion Considerations for WAIHA
- Treatment of WAIHA
- True or False: In a case of WAIHA, the production of IgG or IgG and complement that sensitizes the red blood cells leads to red blood cell destruction...
- Which type of adsorption must be done if a patient has been recently transfused?
- Mixed-Type Autoimmune Hemolytic Anemia
- Drug-Induced Hemolytic Anemia
- Drug-Induced Immune Hemolytic Anemia Introduction
- Mechanisms
- Drug Adsorption Mechanism
- Immune Complex Mechanism
- Membrane Modification (Non-Immune Adsorption of Proteins)
- Induction of Autoimmunity
- Treatment of Drug-Induced Immune Hemolytic Anemia
- Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia
- Which mechanism of drug-induced red cell destruction closely mimics the serologic presentation of warm autoimmune hemolytic anemia (WAIHA)?
- Which mechanism of drug-induced hemolytic anemia involves the formation of drug-antibody combinations that bind non-specifically to RBC membranes and ...
- True or False: Penicillin is one of the medications that may be responsible for the immune complex mechanism of drug-induced hemolytic anemia.
- Case Study One
- Case Study OneA 50-year-old patient with systemic lupus erythematosus (SLE) is admitted to the hospital with evidence of hemolysis, including decrease...
- Case Study One, continued
- Case Study One, continued
- Case Study One, continued
- Case Study OneTo determine the appropriate adsorption technique to use, an accurate transfusion history must be obtained. In this case, the patient ha...
- Case Study OneThe results of the autoadsorbed serum tested with a set of antibody screen cells are shown on the right. What does the pattern of reacti...
- Case Study One Conclusion
- Case Study Two
- Case Study Two
- Case Study Two, continued
- Case Study TwoA DAT is ordered on the patient along with an antibody screen. The DAT is positive and the antibody screen is negative. Elution studies ...
- Case Study Two Conclusion
- References
Additional Information
Level of instruction: Intermediate
Intended audience: Medical laboratory scientists, technicians, and pathologists. This course is also appropriate for medical laboratory science students and pathology residents.
Author information: Erin Tretter, MBA, MT(ASCP), is currently the Rapid Response Laboratory Supervisor at Paoli Hospital. Erin received her Master in Business Administration from the Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor Society. She received her BS in Medical Technology from the California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology, and Chemistry. Erin is currently the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s Hospital for Children and has 7 years of experience teaching immunohematology concepts and laboratory procedures to laboratory science students. She has also taught Blood Bank in the Clinical Laboratory Technician program at the Community College of Philadelphia.
Reviewer information:
Kathy W. Jones, MS, MLS(ASCP)CM is currently an Associate Professor in the Medical Laboratory Science Program at Auburn University Montgomery where she is responsible for the program courses in Clinical Hematology and Clinical Immunology. She holds a BS degree in Biology as well as a Master’s degree in Adult Education from Troy University. She received her Medical Laboratory Science certificate from St. Margaret’s Hospital School of Medical Technology and has over 40 years of experience in laboratory science. Before she became a full-time educator, she served in various roles in the clinical laboratory which included five years as a Hematology Supervisor.
Laurie Bjerklie, MA, MLS(ASCP)
CM is
currently a Content Developer for MediaLab and LabCE. She earned a B.S. in
Medical Laboratory Science from the University of North Dakota
and an M.A. in Curriculum and Instruction from Saint Xavier University. She has
over 15 years of experience in higher education and has held
faculty positions in both MLT and MLS programs. She most recently served as the
Program Manager of Medical Laboratory Science at Saint Louis University.
