(Online CE Course)

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s) Course number 578-022-20, approved through 3/31/2022

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Blood Banking / Immunohematology): 2 hour(s) Course number 20-694787, approved through 9/1/2020

Objectives

• Compare the different types of immune hemolytic anemias.
• Identify and investigate potential serologic discrepancies caused by autoimmune and drug-induced hemolytic anemias.
• Differentiate the four mechanisms involved in drug-induced hemolytic anemias.
• List medications that may be associated with drug-induced hemolytic anemia.

Customer Ratings

(based on 57 customer ratings)

Course Outline

• Immune Hemolytic Anemias
• Introduction
• Direct Antiglobulin Test (DAT)
• Classification of Hemolytic Anemias
• Alloimmune Hemolytic Anemia
• Alloimmune Hemolytic Anemia
• Autoimmune Hemolytic Anemias
• Autoimmune Hemolytic Anemia (AIHA): Introduction
• Symptoms of Autoimmune Hemolytic Anemias
• Testing for Autoantibodies
• Possible Serological and Laboratory Presentations
• True or False: A direct antiglobulin test (DAT) is usually negative in cases of autoimmune hemolytic anemia.
• Cold Autoimmune Hemolytic Anemia
• Cold Autoimmune Hemolytic Anemia
• Cold Hemagglutinin Disease (CHD)
• Paroxysmal Cold Hemoglobinuria (PCH)
• PCH Donath-Landsteiner Test
• ABO/Rh Typing in the Presence of Cold Autoantibodies
• Laboratory Presentations of Cold Autoantibodies - Antibody ID and Detection
• In paroxysmal cold hemoglobinuria (PCH), the autoantibody specificity is most commonly anti-I.
• Cold hemagglutinin disease (CHD) is caused by an IgM antibody with a broad thermal range.
• Warm Autoimmune Hemolytic Anemia
• Warm Autoimmune Hemolytic Anemia (WAIHA)
• Serological Characteristics in WAIHA
• WAIHA Investigation: Serological Findings Following Elution
• Possible Scenarios When Transfusions are Needed in the Presence of WAIHA
• Detection and Identification of An Alloantibody in the Presence of a Warm-Reactive Autoantibody
• Autologous Adsorption (Autoadsorption)
• Allogeneic Adsorption
• Transfusion Considerations for WAIHA
• Treatment of WAIHA
• In a case of WAIHA , the production of IgG or IgG and complement that sensitizes the red blood cells leads to red blood cell destruction.
• Which type of adsorption must be done if a patient has been recently transfused?
• Mixed-Type Autoimmune Hemolytic Anemia
• Mixed Type Autoimmune Hemolytic Anemia (AIHA)
• Drug-Induced Hemolytic Anemia
• Drug-Induced Immune Hemolytic Anemia Introduction
• Mechanisms
• Drug Adsorption Mechanism
• Immune Complex Mechanism
• Membrane Modification (Non-Immune Adsorption of Proteins)
• Induction of Autoimmunity
• Treatment of Drug-Induced Immune Hemolytic Anemia
• Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia
• Which mechanism of drug-induced red cell destruction closely mimics the serologic presentation of warm autoimmune hemolytic anemia (WAIHA)?
• Which mechanism of drug-induced hemolytic anemia involves the formation of drug-antibody combinations that bind non-specifically to RBC membranes and ...
• Penicillin is one of the medications that may be responsible for the immune-complex mechanism of drug-induced hemolytic anemia.
• Case Study
• Case Study OneA 50-year-old female patient with systemic lupus erythematosus (SLE) is admitted to the hospital with evidence of hemolysis, including d...
• Case Study One, continued
• Case Study One, continued
• Case Study One, continued
• Case Study One, continuedTo determine the appropriate adsorption technique to use, an accurate transfusion history must be obtained. In this case the ...
• Case Study One, continued The results of the autoadsorbed serum tested with a set of antibody screen cells are shown on the right. What does the patte...
• Case Study One Conclusion
• Case Study
• Case Study Two
• Case Study Two, continued
• Case Study Two, continuedA DAT is ordered on the patient along with an antibody screen. The DAT is positive and the antibody screen is negative. Eluti...
• Case Study Two, Conclusion
• References
• References