Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia

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The page below is a sample from the LabCE course Immune Hemolytic Anemias. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia

A complete medical history is important when investigating drug-induced immune hemolytic anemia. Patient diagnosis and information about previous transfusions, pregnancies, and medications should be obtained.
  • A DAT should be performed with monospecific reagents.
  • Patient serum should be tested for the presence of alloantibodies by using routine procedures.
  • If no reactivity is observed, the test may be repeated in the presence of the drug.
  • Normal red cells can also be treated and coated with the drug. Negative and positive controls must be tested when using drug-treated red cells. This ensures that any reactivity is interpreted accurately.