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- Development and Purpose of the Laboratory Response Network
- Definition and Role of a Sentinel Laboratory
- Definition of a Sentinel Clinical Laboratory
- Role of a Sentinel Laboratory
- Responsibilities of a Sentinel Clinical Laboratory within the Laboratory Response Network (LRN)
- Any laboratory that analyzes microbes or refers specimens that have the potential to contain microbial agents or toxins is a sentinel laboratory.
- Role of Reference and National Laboratories Within the Laboratory Response Network (LRN)
- What is the role of a sentinel clinical laboratory within the Laboratory Response Network (LRN)?
- Sentinel Clinical Laboratory Protocols
- Additional Resources
- Where can sentinel clinical laboratory staff find the standardized testing protocols?
- Public Health Threats Related to the Agents of Bioterrorism
- Why Certain Agents are Used as Weapons of Mass Destruction (WMD)
- Bacteria, viruses, or toxins that are chosen as weapons of mass destruction (WMD) by bioterrorists are:Easy to acquire and spread Hard to detect and d...
- Categories of Biological Agents
- Category A Agents
- Category A Agents: Reasons Why They May be Used to Create Public Health Emergencies
- Category B Agents
- Category B Agents: Reasons Why They May be Used to Create Public Health Emergencies:
- Category C Agents
- Which of the agent categories is the easiest to spread, has the ability to cause major harm, panic, and death, and carries the highest level of risk w...
- Tier 1 Biological Agents
- Tier 1 biological agents are a subset of select agents and toxins that present the GREATEST risk of deliberate misuse with SIGNIFICANT potential for m...
- Sentinel Laboratory Safety
- The Primary Agents of Bioterrorism
- The Primary Agents of Bioterrorism
- Bacillus anthracis
- Bacillus anthracis: Likely Clinical Specimens and Gram Stain Morphology
- Bacillus anthracis: Culture Characteristics, Colony Morphology, and Hallmark Features
- Bacillus anthracis: Other Diagnostic Tests to Aid in Preliminary Identification
- Yersinia pestis
- Yersinia pestis: Likely Clinical Specimens and Gram Stain Morphology
- Yersinia pestis: Culture Characteristics, Colony Morphology, and Hallmark Features
- Yersinia pestis: Other Diagnostic Tests to Aid in Preliminary Identification
- Francisella tularensis
- Brucella species
- Brucella species: Likely Clinical Specimens and Gram Stain Morphology
- Brucella species: Culture Characteristics, Colony Morphology, and Hallmark Features
- Brucella species: Other Diagnostic Tests to Aid in Preliminary Identification
- Burkholderia species
- Burkholderia species: Likely Clinical Specimens and Gram Stain Morphology
- Burkholderia species: Culture Characteristics, Colony Morphology, and Hallmark Features
- Burkholderia species: Other Diagnostic Tests to Aid in Preliminary Identification
- Practice Questions
- Gram stains are performed on positive blood culture bottles. Match the organism that MOST closely resembles the description of the Gram stain morpholo...
- Which of the following organisms display the characteristic "Medusa head" on sheep blood agar (SBA) after 18 hours of incubation at 35°C?
- Which of the following is NOT a characteristic of Burkholderia pseudomallei?
- Commercial Identification Systems and the Agents of Bioterrorism
- Considerations When Using Automated Identification Systems
- Commonly Misidentified Agents
- Commercial identification systems can reliably identify the bioterrorism threat agents.
- When Should a Sentinel Laboratory Refer an Isolate to a LRN Reference Laboratory?
- Suspect Bacillus anthracis?
- Suspect Yersinia pestis?
- Suspect Francisella tularensis?
- Suspect Brucella species?
- Suspect Burkholderia species?
- When following sentinel laboratory procedures and protocols, any isolate that cannot be ruled out as one of the select agents should be immediately re...
- Indigenous Areas and Disease Encountered Outside of a Bioterrorism Event
- Location Where Organisms Naturally Occur, Disease Produced, and Mode of Transmission
- Location Where Organisms Naturally Occur, Disease Produced, and Mode of Transmission, continued:
- Match the organism to the disease produced outside a bioterrorism event.
- Other Biological Agents: Toxins and Viruses
Level of instruction: Intermediate to advanced
Intended audience: Medical laboratory scientists, medical technologists, and technicians, working in the microbiology section of sentinel laboratories. This course is also appropriate for clinical laboratory science students and pathology residents.
Judi Bennett BSM, MT is a Program Director for MediaLab, Inc. During her 25 year career as a medical technologist, she has served as a Senior System Analyst, laboratory manager, Point-of-Care coordinator, microbiology supervisor, and generalist. Judi has been a speaker at various LIS, AMT, and CLMA conferences and has been published in CLMA magazine.
Laura Stowers MBA, MT(ASCP) received her BS in medical technology from the Medical College of Georgia. She went on to receive her Masters of Business Administration from the University of Georgia. She began working as a medical technologist as a generalist at Gwinnett Medical Center in Lawrenceville, GA and is currently the Supervisor of Microbiology at Gwinnett Medical Center.
Dr. Julie Ann West is certified by the American Society for Clinical Pathology (ASCP) as a Medical Laboratory Scientist (MLS) and as a Specialist in Microbiology (SM). In addition, Dr. West has earned a PhD in Public Health - Infectious Disease Epidemiology - and is Certified in Public Health (CPH) by the National Board of Public Health Examiners. Dr. West is experienced as a Technical Specialist, Safety Officer, Educator, and Lead in the Veterans Administration Healthcare System, and has prior experience as an Administrative Laboratory Director.
Course description: This course provides an overview of the Laboratory Response Network (LRN), including the role and purpose of the front-line clinical laboratories. The course also discusses the indigenous areas where select bioterrorism agents are naturally occurring and can be isolated outside of a public emergency event, the clinical specimens where organisms that are used as bioterrorism agents may be encountered, procedures for the presumptive identification of the primary agents of bioterrorism, and