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The page below is a sample from the LabCE course Antiplatelet Medication Response Testing: Aspirin and Clopidogrel. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Clopidogrel Response Analysis: Optical Light Transmittance Aggregometry

In the same procedure for clopidogrel resistance testing, ADP and other agonists are used to evaluate the effectiveness of clopidogrel's blockade of the P2Y12 (ADP) receptor. Significant inhibition (>50%) of ADP-induced platelet aggregation, with normal platelet response to an alternative agonist, such as thrombin receptor activating peptide (TRAP), indicates successful clopidogrel-induced platelet inhibition. This assay may also be used for other P2Y12 inhibitors such as prasugrel and ticagrelor.