Clopidogrel is used in the treatment of various cardiovascular conditions. These conditions have their own recommended dosages as shown below. Platelet inhibition can often be demonstrated two hours after a single dose of oral clopidogrel. However, the absorption and distribution of the drug may be too slow for some conditions. Therefore, a loading-dose of 300 mg may need to be administered. The table below lists dosage recommendations for various conditions. In all cases, clopidogrel is given orally.
|Recent myocardial infarction (MI), recent stroke, or peripheral arterial disease (PAD)||75 mg once daily|
|Coronary artery disease (CAD)||75 mg once daily|
|Secondary prevention of cardioembolic stroke (patient not a candidate for oral anticoagulation, eg, warfarin)||75 mg once daily|
|Acute coronary syndrome (ACS)||300 mg initially followed by 75 mg daily|