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Factors that May Limit the Effectiveness of Aspirin

Various factors may limit the effectiveness of aspirin, including:
  • Use of enteric coated aspirin
  • Buildup of plaque in blood vessels, causing blood vessel constriction despite the use of aspirin
  • Other medications that prevent aspirin from binding to cyclooxygenase receptors, including nonsteroidal anti-inflammatory drugs (NSAIDs), especially ibuprofen
  • Other blood-clotting processes or other platelet activation pathways that exert a stronger effect than the antiplatelet effect of aspirin
  • Increased platelet turnover
  • Cyclooxygenase enzyme genetic mutations