Mechanism of C-Reactive Protein (CRP)

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The page below is a sample from the LabCE course Laboratory Methods to Aid in the Detection of Sepsis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Mechanism of C-Reactive Protein (CRP)

CRP is an acute phase reactant that is synthesized in the liver. Serum CRP levels increase following a variety of pro-inflammatory events such as infection, tissue necrosis, trauma, surgery, and malignancy. CRP levels can increase quickly and dramatically (often 100-fold) during inflammation. CRP can activate complement, bind Fc receptors and can function as an opsonin, enhancing phagocytosis with certain infections.