Laboratory Methods to Aid in the Detection of Sepsis (Online CE Course)

(based on 1,139 customer ratings)

Author: Lynne Brodeur, MA, MLS(ASCP)
Reviewer: DeRhonda Crawford, MT(ASCP)

This course discusses sepsis and the laboratory tests that are used to detect and intervene in its progression to severe sepsis and septic shock. The usefulness and limitations of C-reactive protein, procalcitonin, and lactic acid concentration are covered in the course. Novel biomarkers that may prove useful as methods for early detection of severe sepsis in the near future are also discussed.

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Course number 578-041-12, approved through 1/17/2017
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Clinical Chemistry/UA/Toxicology): 1 hour(s)
Course number 20-547759, approved through 9/1/2018

Objectives

  • Define sepsis, severe sepsis, and septic shock.
  • Explain how C-reactive protein, procalcitonin, and lactic acid are used to aid in the detection and monitoring of sepsis.
  • Explain the mechanisms of C-reactive protein, procalcitonin, and lactic acid.
  • Discuss novel sepsis biomarkers that are currently being researched.

Customer Ratings

(based on 1,139 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Development and Progression of Sepsis
      • Sepsis Definition
      • Additional Criteria for Diagnosis of Sepsis
      • Severe Sepsis
      • Septic Shock
      • Sepsis and Bacterial Toxins
      • Which of the following are indicators of sepsis?
  • Laboratory Tests Used in the Detection of Sepsis
      • Biomarkers
      • Glucose
      • C-Reactive Protein (CRP)
      • Procalcitonin (PCT)
      • Procalcitonin (PCT) as a Sepsis Biomarker
      • Lactic Acid (Lactate)
      • Lactic Acid (Lactate), continued
      • Which of the following statements regarding a biomarker with high sensitivity is true?
      • C-reactive protein (CRP) is more useful for monitoring response to antibiotics and predicting prognosis than for actual diagnosis of sepsis.
      • Of the three laboratory tests that are listed, which has proven to be most effective for early differentiation of systemic inflammatory response syndr...
      • Blood lactic acid concentration is an indicator of impaired circulation and tissue oxygenation in critically ill patients. If circulation and tissue o...
  • Mechanisms of C-Reactive Protein, Procalcitonin, and Lactic Acid
  • Future Perspectives
  • References
      • References

Additional Information

Level of instruction: Intermediate
Target audience: Medical laboratory scientists, medical laboratory technicians, and MLS students. This course may also be of interest to other health care professionals who are involved in diagnosis and treatment of sepsis. 
Author information: Lynne Brodeur, MA, MLS(ASCP)CM holds a master of arts degree in teaching. She is currently a full time lecturer at the University of Massachusetts Dartmouth and works per diem in Clinical Chemistry at St. Luke's Hospital in New Bedford, MA.
Reviewer information: DeRhonda Crawford, MT(ASCP) is the chemistry supervisor at Gwinnett Medical Center in Lawrenceville, Georgia and the technical supervisor for the Gwinnett Medical Center in Duluth, Georgia. She holds a BS in Medical Technology from the Medical College of Georgia.
Content information: This course discusses sepsis and the laboratory tests that are used to detect and intervene in its progression to severe sepsis and septic shock. The usefulness and limitations of C-reactive protein, procalcitonin, and lactic acid concentration are covered in the course. Novel biomarkers that may prove useful as methods for early detection of severe sepsis in the near future are also discussed. 

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Icterus2586


Lactate production small


PCT values and sepsis


Procalcitonin makeup


sepsis SIRS