Molecular Detection of HPV in Cervical Cytology Specimens

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The page below is a sample from the LabCE course Human Papillomavirus (HPV) and Molecular Testing for Cervical Cancer. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Human Papillomavirus (HPV) and Molecular Testing for Cervical Cancer (online CE course)
Molecular Detection of HPV in Cervical Cytology Specimens

HPV molecular testing involves the detection of HPV viral DNA in cervical cells collected during a pelvic examination. Molecular testing is utilized for detecting high-risk HPV (HR-HPV) types. The testing can be performed as follows:
  • Primary screening for HPV with or without a Pap test
  • Follow-up on abnormal Pap smear cytology
  • Triage of atypical squamous cells of undetermined significance (ASC-US) Pap smear results