Course Outline
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- Human Papillomavirus (HPV)
- HPV as a Virus
- HPV Structure
- HPV Viral Types
- Low-Risk and High-Risk HPV Types
- HPV Genome and Proteins
- Which of the following HPV types are high-risk HPV types and most commonly isolated in cervical caners?
- Select the statement that correctly describes the HPV genome and its encoded proteins.
- HPV as a Sexually Transmitted Infection (STI)
- HPV as a Sexually Transmitted Infection (STI)
- Clinical Diseases Caused by HPV STI Types
- Most genital condylomas and cervical lesions caused by HPV resolve as a result of the immune response in the infected individual.
- Which HPV virus types do not cause cancer but can account for 90% of all genital warts?
- Cervical Cancer and HPV Types
- Overview of Cervical Cancer
- Symptoms, Causes, and Risk Factors for Cervical Cancer
- Staging of Cervical Cancer
- Cervical Cancer Treatment and Prognosis
- Cervical IntraepitheIial Neoplasia (CIN) and Immune Mediated Regression
- Life Cycle of Human Papillomavirus
- Review: Tumor Suppressor Genes, Proto-Oncogenes, and Oncogenes
- Carcinogenesis of Cervical Cancer
- HPV infection can linger for years in cervical cells and eventually convert normal cells into malignant cells.
- Which gene or genes in HPV control(s) the production of E6 and E7 in the normal viral life cycle?
- Papanicolaou (Pap) Test and Cervical Cytology Testing
- Overview of the Pap Smear
- Cervical Cancer Diagnostic Procedures
- _____________ is a diagnostic procedure that examines an illuminated, magnified view of the cervix, vagina, and vulva, usually when an abnormality is ...
- HPV Molecular Diagnostics
- Molecular Detection of HPV
- Review: Nucleic Acids and Molecular Diagnostic Testing
- Molecular Testing Basics
- Hybridization
- Amplification
- Review the descriptions of molecular testing techniques and select the correct statements.
- Types of Molecular HPV Testing
- FDA-Approved HPV Tests
- High-Risk HPV Hybrid Capture (HC) 2 DNA Test
- Cervista HPV DNA
- Cervista HPV DNA, continued
- Comparison of Digene and Cervista HPV DNA Tests
- Cobas HPV Test
- Cobas HPV Test, continued
- Should the HPV Test Be Used as a First-Line Primary Cervical Cancer Screen?
- Should the HPV Test Be Used as a First-Line Primary Cervical Cancer Screen? (continued)
- Which statement is not true when describing the Digene Hybrid Capture 2 High-Risk HPV DNA test?
- The FDA granted the Cobas HPV test the first HPV FDA approval for expanded use of the test to include use as either a co-test or as a primary cervical...
- Updated Guidelines for Cervical Cancer Screening
- Updated Cervical Cancer Screening Guidelines for Pap and HPV Testing
- Prevention of HPV
- References
Additional Information
Level of instruction: Intermediate
Intended Audience: Medical laboratory scientists and technicians and other health care personnel who have an interest in this subject matter. This course is also appropriate for medical laboratory science students, pathology residents, and practicing pathologists.
Author information: Mary Ellen Koenn, MS, MLS(ASCP) is an associate professor emeritus, West Virginia University School of Medicine, Medical Laboratory Science Program. During her career as a medical technologist and educator, she has been a laboratory supervisor and manager and has held several teaching positions. She is the author of numerous articles for laboratory publications and textbook chapters and is a frequent presenter at laboratory seminars and workshops. Ms. Koenn holds a Master of Science degree in Medical Technology.
Reviewer information: Laurie Bjerklie, M.A., MLS(ASCP)CM is
currently a Content Developer for MediaLab and LabCE. She earned a B.S. in
Medical Laboratory Science from the University of North Dakota
and an M.A. in Curriculum and Instruction from Saint Xavier University. She has
over 14 years of experience in higher education and has held
faculty positions in both MLT and MLS programs. She most recently served as the
Program Manager of Medical Laboratory Science at Saint Louis University.
Course Description: This course discusses the various types of human papillomavirus and their association with cervical cancer. Molecular methods of detection are discussed, beginning with a basic review of nucleic acid amplification methods and hybridization methods. Two FDA-approved methods for molecular HPV testing are briefly explained. The course also presents four case studies to demonstrate the correct and incorrect utilization of HPV molecular methods.
