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Disseminated Intravascular Coagulation (DIC)

DIC is a condition that is usually secondary to an underlying disease or condition. Some of the activators of DIC are sepsis, placenta abruptio, snake bites, toxin, trauma, graft vs. host disease, and burns.

The mechanisms that are involved in DIC include a hyperactivated coagulation system, a hyperactivated fibrinolytic system, or both simultaneously. In most cases the coagulation factors are consumed as soon as they are made and platelets are also consumed in the coagulation process. Clots are made rapidly and then rapidly destroyed as the fibrinolytic system is hyperactivated.