Preanalytic Variable Leading to False Thrombocytopenia

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Preanalytic Variable Leading to False Thrombocytopenia

The platelet count is only as good as the sample collected. Blood samples collected in EDTA or sodium citrate tubes for coagulation purposes should be inverted 5 - 10 times for proper mixing of the anticoagulant and the blood. If the tube is not mixed, small fibrin clots may form (similar to those found in the image to the right), causing a falsely decreased platelet count.

Inverting EDTA specimen.
Arrows pointing out platelet clumping on a peripheral blood smear.