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The page below is a sample from the LabCE course Hemoglobinopathies: Hemoglobin S Disorders. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Genetic Testing

Sickle cell disease was one of the first diseases to which diagnosis using DNA analysis was used. Polymerase chain reaction (PCR) can be employed to amplify and identify the S gene. Variations of the PCR techniques are being employed to speed-up or simplify the traditional PCR, such as real-time PCR, single-tube allele specific PCR, and others.
The use of genetic identification of the S gene is especially important in pre-natal diagnosis, or for genetic screening of expectant parents.