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The page below is a sample from the LabCE course Hemoglobinopathies: Hemoglobin S Disorders. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Blood Flow During Sickling

RBCs with sickle hemoglobin (HbSS) undergo changes during deoxygenation that may make them less deformable in the smaller blood vessels. The lack of deformability and cellular interactions cause a slowing down of the blood flow in affected blood vessels. Eventually, occlusion may result.