The Sickling Process

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 180 CE courses, most popular
$109Add to cart
Pick Your Courses
Up to 8 CE hours
$55Add to cart
Individual course$25Add to cart
Need multiple seats for your university or lab? Get a quote
The page below is a sample from the LabCE course Hemoglobinopathies: Hemoglobin S Disorders. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Hemoglobinopathies: Hemoglobin S Disorders (online CE course)
The Sickling Process

Normally, there is no interaction between hemoglobin molecules. The substitution of valine for glutamic acid in the beta six position allows for an abnormal interaction between the beta chains, in which the beta 6 valine fits into a pocket between beta 85 and beta 88 on an adjacent molecule.