Case Study Summary

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The page below is a sample from the LabCE course The Disappearing Antibody: A Case Study. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about The Disappearing Antibody: A Case Study (online CE course)
Case Study Summary

This case study presents a scenario in which a patient had an unexpected antibody that disappeared after he was transfused with unmatched group O Rh negative Red Blood Cells.

The patient developed a positive direct antiglobulin test (DAT) with mixed-field agglutination (MFA). An antibody identification using the post-transfusion red cell eluate was inconclusive, making the antibody unidentifiable. Fortunately, the patient improved and further transfusion was not required.

Ultimately, the patient's antibody was identified as anti-Jka, with a second antibody to a low frequency antigen (Radin) also unexpectedly present.

The case illustrates the risks involved in using unmatched blood.