This case study presents a scenario in which a patient had an unexpected antibody that disappeared after he was transfused with unmatched group O Rh negative Red Blood Cells.
The patient developed a positive direct antiglobulin test (DAT) with mixed-field agglutination (MFA). An antibody identification using the post-transfusion red cell eluate was inconclusive, making the antibody unidentifiable. Fortunately, the patient improved and further transfusion was not required.
Ultimately, the patient's antibody was identified as anti-Jka, with a second antibody to a low frequency antigen (Radin) also unexpectedly present.
The case illustrates the risks involved in using unmatched blood.