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The page below is a sample from the LabCE course Hematopoietic Stem Cell Transplantation. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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ABO Incompatibility in HSC Transplants

Incompatibilities in ABO blood groups can result in a hemolytic anemia that may require transfusion or erythropoietin therapy. ABO incompatibilities reportedly have not caused GVHD or transplant rejection. If the patient has a high antibody titer they can receive a red cell-depleted transplant. Methotrexate is also used to prevent hemolysis. Incompatibilities caused by anti-patient antibodies in the donor can be reduced by plasmapheresis.