Course Outline
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- Overview and History
- Hematopoietic Stem Cells
- Hematopoietic Stem Cells (HSCs)
- Progenitor Cells
- Important Definitions
- Which CD antigen is present on hematopoietic stem cells (HSCs)?
- Sources of Hematopoietic Stem Cells
- Sources of Hematopoietic Stem Cells: Bone Marrow
- Sources of Hematopoietic Stem Cells: Peripheral Blood
- Sources of Hematopoietic Stem Cells: Umbilical Cord Blood
- What is the most frequent source of HSCs used for transplantation?
- Which allogeneic HSC donation procedure is most commonly used today?
- Preservation and Infusion of HSCs
- Preservation and Infusion of HSCs
- Preservation and Infusion of HSC's, continued
- What agent is used as a cryopreservative for long-term storage of HSCs?
- Scenario: A transplant patient is tested for T cells after immunosuppression therapy. The following data is obtained by flow cytometry from the patien...
- Successful engraftment of a hematopoietic stem cell transplant depends on many factors. Which of the following choices are associated with a graft fai...
- Human Leukocyte Antigen Testing for HSC Transplantation
- Human Leukocyte Antigens (HLAs) and HSC Transplantation
- HLA's and HSC Transplantation, continued
- Donor and Recipient Testing of Human Leukocyte Antigens (HLAs)
- Match the class of the MHC antigens with the appropriate term/description.
- What type of specimen is used for HLA typing of prospective donors by the National Marrow Donor program?
- Recruiting and Matching Donors with Patients
- Finding Donors for Transplant Patients
- Donor Requirements and Testing
- Matching Donors with Transplant Recipients
- What US organization has as its major goal, the recruitment of donors for allogeneic HSC transplants?
- Which of the following would exclude a potential HSC donor from the National Marrow Registry?
- Preparing the Patient for Transplant
- Hematopoietic Diseases Treatable by HSCs
- Treatment of Hematologic Diseases by HSC Transplantation
- Which of the following would be the treatment of choice for a pediatric patient with acute lymphoblastic leukemia (ALL) who had acute GVHD from a prio...
- Which hematologic malignancy is most commonly treated with an allogeneic HSC transplant?
- Nonhematopoietic Diseases Treated by HSCs
- Complications of HSC Transplantation
- Graft versus Host Disease
- Graft Failure
- Relapse
- Infection
- Late Effects After HSC Transplantation
- ABO Incompatibility in HSC Transplants
- Graft Versus Tumor Effect
- What is the most likely cause of secondary malignancy in HSC transplant patients?
- What laboratory test result might indicate that a patient is experiencing GVHD?
- Which of the following factors may precipitate a graft versus host disease (GVHD) reaction to occur?
- Acknowledgements
- References
Additional Information
Level of Instruction: Beginning to intermediate
Intended audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for clinical laboratory science students and pathology residents.
Author information: David Falleur, M.Ed, MT(ASCP) is an Associate Professor in the Clinical Laboratory Science Program at Texas State University in San Marcos, Texas. David has more than 40 years of teaching experience in hematology and clinical chemistry. David has been active at the national level serving as Annual Meeting Chair for the ASCLS Annual Meeting in 2015 and at the state level as President of the Texas Association for Clinical Laboratory Science.
Reviewer information: Leah Coppolino, MPH, MLS(ASCP) is a Program Director for MediaLab, Inc. Leah was previously the Director of the Medical Laboratory Science Program at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.
Course description: Hematopoietic stem cell (HSC) transplantation has become a procedure that offers hope to many patients with cancer and other life-threatening diseases. This course aims to provide information about the importance of HSC transplantation and the role played by the clinical laboratory in HSC collection, processing, administration, and the patient's ongoing care after transplant. The sources of HSCs used in transplants, their application in the treatment of malignant and nonmalignant disorders, and the complications associated with HSC transplantation are also discussed.
