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The page below is a sample from the LabCE course Beta Thalassemia. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Chromosome 11 Beta Thalassemia Major

Beta thalassemia major, B0/B0 (two gene mutations, deletions or combination) results in very few to no beta chains being produced.

Hemoglobin A levels are at or near 0%.

(drawing modified from Harmening, 1999)

Other genotypes of beta thalassemia major not depicted include B0/B+ (one beta chain deleted, one partially deleted) and B+/B+ (both beta chain genes partially deleted).