Factors Promoting Cast Formation

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The page below is a sample from the LabCE course The Urine Microscopic: Microscopic Analysis of Urine Sediment. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Factors Promoting Cast Formation

The following factors promote the formation of casts in the kidney:

  • Larger than normal amounts of plasma proteins entering the tubules
  • Decreased pH
  • Decreased urinary flow rate (urinary stasis)
  • Increased urine concentration (increased specific gravity)
After formation, casts are loosened from the tubules and discharged into the urine.