Latent Mycobacterium tuberculosis Infection and Laboratory Test Methods (Online CE Course)

(based on 534 customer ratings)

Julie Ann West, PhD, MLS(ASCP)CM, SM(ASCP)CM
Reviewer: Christine Mayambala, PhD, MLS(ASCP)CM

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This course provides information about the difference between active tuberculosis (TB) disease and latent tuberculosis infection (LTBI), etiology, pathogenesis, and distribution both in the US and globally. Targeted testing of individuals (based on risk factors), as well as laboratory testing methods (to include the tuberculin skin test [TST] and interferon gamma release assay [IGRA]) are described. An emphasis on laboratorian troubleshooting of aberrant results is included. The course concludes with a brief description of recommended treatment and management regimens for LTBI (including the role of laboratory in the monitoring of infected individuals).

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Approved through 1/31/2025
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Microbiology/Mycology/Parasitology): 1 hour(s)
Approved through 1/31/2025

Objectives

  • Describe the difference between active tuberculosis [TB] disease and latent tuberculosis infection [LTBI], list terms and abbreviations.
  • Describe the etiology (cause of disease) and pathogenesis (manner of development) of TB disease and LTBI.
  • Review the epidemiology (occurrence and distribution) of TB disease and LTBI in the United States (US) and globally.
  • Targeted testing: Describe who should be tested for TB infection (risk factors).
  • Describe recommended TB test methods, interpretations, and limitations (TB skin test [TST] versus laboratory TB blood tests to include interferon-gamma release assays [IGRA]).
  • Describe recommended treatment and management regimens for patients with LTBI (to include laboratory monitoring).

Customer Ratings

(based on 534 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Introduction
      • Introduction
      • Historical Background
      • What is the Difference Between LTBI and Active TB?
      • Terminology
      • List of Terms and Abbreviations
      • Which of the following statements is correct regarding LTBI?
      • Select the statement which best corresponds to the abbreviation: IGRA.
  • Etiology and Pathogenesis of TB Disease and LTBI
      • Etiology: What is the Cause of Tuberculosis?
      • Pathogenesis: What is the Process by which Tuberculosis (TB) Develops?
      • Pathogenesis: What is the Process by which Latent Tuberculosis Infection (LTBI) Develops?
      • Pathogenesis: Risk of Activation from LTBI to Active TB Disease
      • Individuals with latent tuberculosis infection (LTBI) experience what immune response?
      • Expected laboratory findings in a case of latent tuberculosis infection (LTBI) might be:
      • The risk of activation from LTBI to active TB disease is approximately 17-20% over an individual's lifetime.
  • Epidemiology
  • Targeted Testing: Who Should be Tested?
      • Targeted Testing: Who Should be Tested for TB Infection?
      • Targeted Testing: Who Should be Tested for TB Infection? (continued...)
      • Special Consideration: Those Vaccinated with Bacille Calmette-Guerin (BCG) Vaccine
      • Persons at high risk for TB infection fall into which two broad categories?
      • Which statement best reflects people at high risk for TB infection or TB disease after infection? (Those targeted for testing?)
  • TB Test Methods
  • Treatment and Management
      • Recommended Treatment Regimens for LTBI
      • Recommended Treatment Regimens for LTBI (continued...)
      • Recommended Patient Management Regimen for LTBI
      • In Summary
      • Duration of drug treatment for LTBI may be as short as three months (12 total doses) and includes:
      • Patient management for individuals on drug treatment for LTBI include:
  • References

Additional Information

Level of instruction: Intermediate
Intended audience: This course is intended for microbiology and immunology bench technicians and technologists, supervisors, and administrators.
Author information: Dr. Julie Ann West is certified by the American Society for Clinical Pathology (ASCP) as a Medical Laboratory Scientist (MLS) and as a Specialist in Microbiology (SM). In addition, Dr. West has earned a PhD in Public Health - Infectious Disease Epidemiology and is Certified in Public Health (CPH) by the National Board of Public Health Examiners. Dr. West is experienced as a Technical Specialist, Safety Officer, Educator, and Lead in the Veterans Administration Healthcare System, and has prior experience as an Administrative Laboratory Director.
Reviewer information: Christine Mayambala, PhD, is certified by the American Society for Clinical Pathology (ASCP) as a Medical Laboratory Scientist (MLS). She has earned a PhD in Public Health - Epidemiology Specialization. Dr. Mayambala is experienced as a Generalist and Molecular Technologist. At present, Dr. Mayambala teaches pre-nursing and medical laboratory technology at a community college in Metro Atlanta.
Course description: This course provides information about the difference between active tuberculosis (TB) disease and latent tuberculosis infection (LTBI), etiology, pathogenesis, and distribution both in the US and globally. Targeted testing of individuals (based on risk factors), as well as laboratory testing methods (to include the tuberculin skin test [TST] and interferon gamma release assay [IGRA]) are described. An emphasis on laboratorian troubleshooting of aberrant results is included. The course concludes with a brief description of recommended treatment and management regimens for LTBI (including the role of laboratory in the monitoring of infected individuals).

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 181 CE courses, most popular
$109Add to cart
Pick Your Courses
Up to 8 CE hours
$55Add to cart
Individual course$25Add to cart
Administering the TST. (7)


Reading the TST. (8)


Take on Latent TB Infection. (2)


This photomicrograph of a Ziehl-Neelsen-stained specimen,</br> revealed the presence of magenta stained, rod-shaped,</br> acid-fast, Mycobacterium tuberculosis bacilli. (3)


Tuberculosis (TB) Disease: Only the Tip of the Iceberg. (4)


Two-step TST Testing. (9)