Course Outline
Click on the links below to preview selected pages from this course.
- Introduction
- Thyroid Anatomy and Histology
- Overview of the Anatomy of the Thyroid Gland
- Thyroid Gland: Location
- Locating the Thyroid Gland
- Thyroid Gland: Structure
- Structure of the Thyroid Gland
- Which statement is true regarding the thyroid?
- Thyroid Gland: Histological Features
- Histological Features of the Thyroid Gland
- Thyroid Function
- An Overview of Thyroid Function
- Thyroid's Roles in Metabolism and Metabolic Rate
- Metabolism and Metabolic Rate
- Other Endocrine Roles
- Biochemistry of Thyroid Hormones
- Thyroxine (T4)
- Assembly of the T4 Molecule
- Triiodothyronine (T3)
- Total and Free Forms of T3 and T4
- Total and Free Forms of T3 and T4
- What components are required to assemble thyroid hormones?
- Endocrinological Relationships
- The Thyroid Gland's Relationship within the Endocrine System
- Pituitary Gland
- The Pituitary Gland and Regulation of Thyroid Function
- Thyroid-Stimulating Hormone (TSH)
- Hypothalamus
- Parathyroid Glands
- Parathyroid Glands in Relation to the Thyroid
- Disorders of the Thyroid Gland
- Euthyroid
- Hypothyroidism
- Hyperthyroidism
- Autoimmune Disorders of the Thyroid
- Neoplasm and Malignant Conditions
- Benign and Malignant Hyperplasias of the Thyroid: Overview
- Benign Hyperplastic Conditions
- Malignant Thyroid Hyperplastic Conditions
- True or False: Benign hyperplastic conditions of the thyroid may lead to an overproduction of functional thyroid hormones and present with symptoms of...
- Laboratory Analysis of Thyroid Markers
- Analytical Methods for Thyroid Hormone Measurement
- TSH
- Analysis of Thyroid-Stimulating Hormone (TSH)
- Thyroid-Stimulating Hormone (TSH) Screening Recommendations
- Hormones Produced by the Thyroid Gland
- Reverse T3
- Analysis of Reverse T3 (RT3)
- T-Uptake
- Free Thyroxine Index
- Historical Estimation of the Free Thyroxine Index (FTI)
- Thyroglobulin
- Analysis of Thyroglobulin (Tg)
- Thyroglobulin Antibody (TgAb)
- Thyroperoxidase Antibody (TPOAb)
- Analysis of Thyroperoxidase Antibody (TPOAb)
- True or False: The sensitivity of thyroid function testing has improved through the development of immunoassay methods with enhanced detection capabil...
- Clinical Case Studies
- Clinical Case Study #1
- Clinical Case Study #2
- Secondary Hyperthyroidism: Case Report
- References
Additional Information
Level of Instruction: Basic
Intended Audience: Medical laboratory scientists and medical laboratory technicians seeking review, cross-training, or continuing education opportunities. This course is also appropriate for medical laboratory science students, medical students, and pathology residents.
Author Information: Jack A. Maggiore, PhD, MT(ASCP) serves as the Assistant Laboratory Director of Chemistry and is Head of Research and Development at Doctor's Data, Inc. in Saint Charles, Illinois. Dr. Maggiore is a medical technologist, certified by the ASCP, with a Master of Science in Clinical Chemistry and a Doctorate in Pathology from the University of Illinois. His expertise includes clinical instrumentation, method development and validation, quality assurance, medical device clinical trials, and scientific regulatory affairs. His clinical research interests include development of novel biomarkers for chronic diseases using blood spots and other non-conventional samples. Dr. Maggiore holds several medical device patents, has authored more than fifty peer-reviewed and invited publications and textbook chapters, and has presented his research findings at international scientific society meetings. Dr. Maggiore's mission is to work with health care professionals to empower consumers to take a more active role in their health maintenance.
Reviewer Information: Roger Beckering, M.Ed., BA (Chemistry), MLT(ASCP) has been an educator of medical laboratory sciences for over 25 years. He started as an instructor at the Medical Institute of Minnesota (MIM), later known as Argosy University. At Argosy, Roger held positions as Professor, Clinical Coordinator, and Program Director. In 2014, Roger moved to the Phoenix area where he works as a Professor and Administrator for MLT and MLS programs at Brookline College.
Course Description: The material presented in this course is intended to explain the role of the laboratory in diagnosing thyroid conditions/diseases and in determining the effectiveness of thyroid treatment. The basic biochemistry of the thyroid hormones and the feedback mechanism between the thyroid and pituitary will be discussed, as well as thyroid disorders and the assays used to assess thyroid function.
