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Transfusion Reactions (Online CE Course)

(based on 1,076 customer ratings)

Author: Erin Tretter, MT(ASCP)
Reviewer: Barbara Cebulski, MS, MLS(ASCP)

What are the risks associated with blood transfusion? As a laboratory professional involved in blood preparation for transfusion, do you know what steps you can take to minimize those risks? If a patient starts to exhibit various symptoms during or after a transfusion, would you know how to interpret those symptoms and what actions to take to prevent harm to the patient? These are all important questions that are asked and answered by our new course, Transfusion Reactions. This course covers important types of transfusion reactions, including acute hemolytic transfusion reactions, transfusion-related acute lung injury, and transfusion-associated graft versus host disease. If you are a part of the health care team that is involved in the processing and administration of blood products, this course will reinforce those policies and procedures that you may already know, but are important to review. This course will update your knowledge about the various types of reactions that occur and their associated symptoms. Even though you may not be involved in the clinical part of the transfusion process, it is important to understand the big picture to recognize how important your job is to ensure patient transfusion safety.

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Continuing Education Credits

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Blood Banking / Immunohematology): 1.5 hour(s)
Course number 20-547963, approved through 9/1/2018

Objectives

  • Define transfusion reaction.
  • Identify the risks of transfusions.
  • Compare and contrast immediate hemolytic transfusion reactions and delayed hemolytic transfusion reactions.
  • List and define the types of nonhemolytic transfusion reactions.
  • List the laboratory findings associated with hemolytic and nonhemolytic transfusion reactions.
  • Discuss the definition, pathophysiology, signs, symptoms, therapies, prevention, and clinical work-up of hemolytic and nonhemolytic transfusion reactions.
  • List the antibodies associated with hemolytic transfusion reactions.
  • List the steps and procedures to follow in a laboratory investigation of a transfusion reaction.

Customer Ratings

(based on 1,076 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Adverse Effects of Blood Transfusions
  • Blood Component Transfusion Risks
  • Acute Immunologic Transfusion Reactions
    • Acute Hemolytic Transfusion Reactions
      • Causes of Acute Hemolytic Transfusion Reaction (AHTR)
      • Clinical Signs and Symptoms
      • Initial Transfusion Reaction Investigation
      • Additional Testing
      • Management and Prevention
      • An acute hemolytic reaction may be caused by which of the following? (Choose all that apply)
    • Febrile Transfusion Reactions
      • Febrile Nonhemolytic Transfusion Reactions: Definition, Manifestation, and Prevalence
      • Diagnosis, Treatment, and Prevention of FNHTR
    • Allergic Transfusion Reaction
    • Transfusion-Related Acute Lung Injury (TRALI)
      • Definition and Epidemiology
      • Clinical Presentation and Laboratory Findings
      • Pathophysiology
      • Diagnosis, Treatment, and Prognosis
      • Prevention of Transfusion-Related Acute Lung Injury (TRALI)
      • Which type of antibodies are known to cause transfusion-related acute lung injury (TRALI) reactions?
  • Acute Nonimmunologic Transfusion Reactions
  • Summary of Additional Testing in Acute (Immediate) Transfusion Reaction Investigations
      • Table: Additional Testing That May Be Ordered for Acute (Immediate) Transfusion Reaction Investigations
  • Delayed Immunologic Transfusion Reactions
    • Delayed Hemolytic Transfusion Reactions
      • Delayed Hemolytic Transfusion Reaction (DHTR)
      • DHTR: Diagnosis
      • Severe DHTR and Sickle Cell Anemia
      • Delayed hemolytic transfusion reactions (DHTR) typically occur 3 hours after transfusion.
    • Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD)
    • Post-Transfusion Purpura (PTP)
      • Definition/Manifestation/Prevalence
      • Pathophysiology, Treatment, and Prevention of Post-Transfusion Purpura (PTP)
      • Which of the following patients are at risk for transfusion-associated graft versus host disease (TA-GVHD) and require irradiated cellular blood produ...
      • Post-transfusion purpura (PTP) is characterized by which of the following?
  • Delayed NonImmunologic Transfusion Reactions
      • Iron Overload
      • Disease Transmission
  • Investigation of a Delayed Transfusion Reaction
      • Investigation of a Delayed Transfusion Reaction
  • Reporting Transfusion Reactions
      • Recording and Reporting Transfusion Reactions
  • References
      • References

Additional Information

Level of instruction: Intermediate
 
Intended audience: Medical laboratory scientists, medical technologists, and technicians, This course is also appropriate for clinical laboratory science students and pathology residents.
Author information: Erin Tretter, MT(ASCP), is currently the Point of Care Coordinator and Lead Medical Technologist at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She received her BS in Medical Technology from California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology and Chemistry. Erin is the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s and has four years experience teaching immunohematology concepts and laboratory procedures to Medical Technology students. She has also provided blood bank training for laboratory technologists and medical students. Erin is currently obtaining a Master’s in Business Administration from Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor’s Society.
 
Reviewer information: Barbara Cebulski, MS, MLS(ASCP) has over 40 years of experience in the medical laboratory profession as a technologist, section supervisor, and laboratory manager. She was an Inspection and Technical Specialist for nine years with the College of American Pathologists in the Laboratory Accreditation Program and, until her retirement in 2015, was Program Director for MediaLab, Inc. Barbara holds a Masters in Instructional Technology from Georgia State University.
 
Course information: This course is a review of clinical and laboratory recognition of transfusion reactions and the responsibilities of both areas for prevention of and proper response to a suspected reaction. 

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Keywords

These are the most common topics and keywords covered in Transfusion Reactions:

philadelphia methods lysis anamnestic silberstein symptoms physician peptide anemias saline radiograph antigen-antibody oliguria edema intracellular heart identification concentration alloimmunization transfused hypotension ness environment lung symptom ucm205620 treatment antibody records transfusionist trali dyspnea rbcs sickle cytokines dhtr eligibility disinfection livingstone potassium churchill exposure platelets hypoxemia fnhtr crossmatch antigens bilirubin downloads errors red blood cell hemolysis transfusiondonationfatalities infection reportaproblem post-transfusion airway procedures ahtr contamination hematocrit infectious leukocyte bacteria alloantibody blood fnhtrs medication differential contaminated plasma disease toxicity taco natriuretic anaphylactoid rigors red blood cells immune-mediated diuretics reticuloendothelial clinical diarrhea abdominal arrhythmias drug coagulation laboratory body autologous pre-transfusion ta-gvhd safetyavailability histamines non-hemolytic urine antigen organisms misidentification blood banking immunodeficiency scrub fetuses donate anderson premedication hemolytic chemical tubing dhtrs pregnancy urticarial soluble organs neonates intravenous appears alloantibodies multiparous endotoxins febrile respiratory transfusion-associated annual diagnosis granulocyte cellular anti-hla immunocompromised roback stem liver fatalities providers acute cells indefinitely glucose bilateral antiglobulin extravascular lymphocytes hemoglobinuria label bone marrow diseases donors oxygen immune hives donor hemoglobin pathophysiology medicine cardiac transfusion-related allergic adverse citrate b-type pre-storage anemia anti-iga blood bank pathogens serologic biologicsbloodvaccines infiltrates serum transfusions urinalysis transfusion bacterial antibodies jaundice mast cells allergen thrombocytopenia urinary anaphylactic cryoprecipitate deficiency evaluation hillyer matched intravascular samples hypersensitivity platelet labeling nonhemolytic allows
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