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- Definitions and Background
- Key Definitions
- The Ideal Tumor Marker
- The Ideal Tumor Marker Would Have 100% Specificity
- The Ideal Tumor Marker Would Have 100% Sensitivity
- Concentration and Tumor Mass
- The Ideal Tumor Marker Would Be Indicative of Tumor Mass
- Analytical Aspects
- Providing Diagnostic and Prognostic Support
- Examples of Tumor Markers
- Primary and Ectopic Hormones
- Example of Ectopic Production of Hormone from Lung Tumor
- Hormones as Tumor Markers
- In regards to hormone production, what is the term that is associated with the production of a hormone at a distant site by non-endocrine tissue?
- Specific Proteins
- Specific Proteins as Tumor Markers
- Specific Proteins as Tumor Markers - Monoclonal Immunoglobulins
- Specific Proteins as Tumor Markers - Diagnostic Utility
- The detection of an immunoglobulin clone, such as IgM, is ALWAYS associated with a malignant condition, such as a multiple myeloma.
- Carbohydrate Markers
- Carbohydrate Tumor Markers
- The Mucin-Rich Carbohydrate Tumor Markers
- CA 125
- CA 15-3
- CA 549
- CA 27.29
- Blood Group Antigen-Related Cancer Markers
- Oncofetal Antigens
- The Oncofetal Antigens
- Alpha Fetoprotein (AFP)
- Carcinoembryonic Antigen (CEA)
- Mutations of Tumor Suppressor Genes
- Breast Cancer Susceptibility Proteins
Level of instruction: Beginning
Intended audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.
Author information: Jack A. Maggiore, PhD, MT(ASCP) serves as the Assistant Laboratory Director of Chemistry and is Head of Research and Development at Doctor's Data, Inc. in Saint Charles, Illinois. Dr. Maggiore is a medical technologist, certified by the ASCP, with a Master of Science in Clinical Chemistry and Doctorate in Pathology from the University of Illinois. His expertise includes clinical instrumentation, method development and validation, quality assurance, medical device clinical trials, and scientific regulatory affairs. His clinical research interests include development of novel biomarkers for chronic diseases using blood spots and other non-conventional samples. Dr. Maggiore holds several medical device patents, has authored more than fifty peer-reviewed and invited publications and textbook chapters, and has presented his research findings at international scientific society meetings. Dr. Maggiore's mission is to work with health care professionals to empower consumers to take a more active role in their health maintenance.
Reviewer information: Lisa Dewey, MT(ASCP) is the Quality Manager at Doctor's Data, Inc. and has been a medical technologist since 1990. She obtained a BS in Clinical Laboratory Science from the University of Illinois at Chicago. Lisa has experience working in various specialties in hospital and clinic laboratories, research & development, laboratory management, and a commercial laboratory specializing in dried blood spot testing.
Course description: This course is intended to provide the basic information necessary regarding tumor markers and how they are used to detect, diagnose, and provide a prognosis of various cancers, as well as to provide an increased understanding of the many emerging biomarkers.