In addition to CLSI, other researchers have also reported on antibiotic resistance in various Corynebacterium species. Resistance has been reported in C. amycolatum, C. diphtheriae, C. jeikeium, C. propinquum, C. striatum, C. tuberculostearicum, C. urealyticum, as well as additional isolates not covered in this course. These isolates have shown resistance to ß-lactams, aminoglycosides, macrolides, and quinolones.
According to CLSI, most Corynebacterium isolates studied have been shown to be susceptible to daptomycin (99.6%) and 85% of isolates reviewed in the literature are susceptible to rifampin, tetracycline, gentamicin, and meropenem. All Corynebacterium reported in the literature remain susceptible to tigecycline, linezolid, and vancomycin.
While there is limited data for susceptibility and resistance mechanisms for other coryneform organisms, it does appear that reduced susceptibility to daptomycin is relatively common. There have also been reports of resistance to tetracycline for Arcanobacterium haemolyticum and Trueperella bernardiae. Arthrobacter species have shown resistance to quinolones and aminoglycosides, and some Brevibacterium species may show resistance to clindamycin and ß-lactam drugs. Some Leifsonia and Microbacterium isolates have been reported to have reduced susceptibility to vancomycin.
39. Clark, W. A. "Corynebacterium aquaticum Gram stain." CDC Public Health Image Library (PHIL). Public domain. 1977. Accessed July 28, 2023. https://phil.cdc.gov/Details.aspx?pid=15804
