The page below is a sample from the LabCE course White Cell and Platelet Disorders: Peripheral Blood Clues to Nonneoplastic Conditions. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Pelger-Huet Anomaly

Pelger-Huet anomaly is a congenitally acquired condition of nuclear segmentation that has no clinical significance. There is no loss of cellular function.
The condition can be suspected if typical bilobed, "pince-nez" nuclei are observed (see top image on the right). Band neutrophils usually have two distinct lobes, connected by a relatively short but thick bridge. Monolobulated cells may also be encountered, especially if a homozygous inheritance is present, as illustrated in the bottom image on the right. If 70% or more of the segmented neutrophils on the differential possess these nuclear morphologies, the possibility of a homozygous Pelger-Huet should be considered.