The Powassan virus is a Flavivirus related to West Nile virus and is spread primarily by Ixodes scapularis in the United States. The disease is seen most often in the Northeast and upper Midwestern states. It may be asymptomatic, or symptoms may occur after an incubation period of one week to one month after the tick bite. Symptoms may include:
- Headache
- Fever
- Weakness
- Confusion
- Loss of coordination
- Speech difficulties
- Seizures may be seen in meningitis and encephalitis
The CSF will have a lymphocytic pleocytosis of less than 500 white blood cells/mm3. Half of the symptomatic cases have residual diseases, such as chronic headaches, memory problems, and muscle wasting. Of those cases diagnosed with encephalitis, 10% are fatal. Diagnosis is mainly by PCR because cell culture is complex and seldom productive. Diagnosis can also be made by testing neutralizing antibodies in acute and convalescent sera.
