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The page below is a sample from the LabCE course Theoretical and Practical Aspects of Routine H&E Staining. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Why is the H&E Stain the Most Common?

Think of the H&E stain as a triage stain. It is used as an initial screening. It gives an overview of the structure of the tissue being examined and enables these structures to be differentiated from one another. From this, the pathologist can determine if the tissue is normal or pathological.

Often, a diagnosis can be made based on the H&E alone. However, after reviewing the H&E slides, special staining may be necessary to make a more specific diagnosis.