Why is Calibrator Analysis Important?

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The page below is a sample from the LabCE course Calibration of Clinical Laboratory Analytes. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Calibration of Clinical Laboratory Analytes (online CE course)
Why is Calibrator Analysis Important?

No matter the analytic methodology, almost all analytical responses experience drift over time. This drift may be due to:
  • aging of specific analyzer components
  • changes in detector specifications
  • alterations in the surrounding environment, such as
    • temperature
    • humidity
    • light
Calibration, or recalibration, effectively re-establishes the response associated with the true analyte concentration, correcting many analytical changes caused by drift.

Multiple gradual drifts down followed by recalibration to reset quantitation.