Test inaccuracies are a significant issue for both IHC and FISH.
Pre-examination, examination, and post-examination factors can affect test accuracy. Using laboratory assays as the sole determinant for therapy selection poses a significant challenge to pathologists performing and interpreting the results and oncologists who must rely on them for clinical decisions.
IHC and FISH are important testing procedures that dictate critically effective yet potentially life-threatening and expensive treatment. Assay standardization is critical to reducing the occurrence of inaccurate testing.
This image is of a HER2 IHC-stained tissue section. The score for this slide would be 3+. It has complete membrane staining.
