MDMA

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The page below is a sample from the LabCE course Drug Testing Methods in the Clinical Toxicology Laboratory. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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MDMA

MDMA (3,4 dimethoxymethamphetamine) is a synthetic compound that is not found in nature. It is structurally similar to the amphetamines. Known as 'ecstasy', this drug has unique stimulant properties that make it distinct from amphetamines.
About 20% of MDMA is excreted in the urine unchanged. The elimination half-life is approximately seven hours but, like amphetamines, alkaline urine can increase the half-life of MDMA to 16-31 hours.
Since the cross-reactivity of MDMA and its metabolites in amphetamine immunoassays is very low, most laboratories employ the use of a separate MDMA screen in addition to the amphetamine screen.