The page below is a sample from the LabCE course Body Fluid Differential Tutorial. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Acute Myeloid Leukemia (AML)

This cytospin is from a patient diagnosed with acute myeloid leukemia (AML) who had central nervous system involvement at the time of diagnosis.

Notice the large size of these blasts. They have very fine, soft chromatin with very prominent multiple nucleoli. The cytoplasm has a hint of the background granularity that myeloid blasts have on a peripheral smear. These characteristics help to identify immature myeloid blast cells in fluid differential analysis.