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The page below is a sample from the LabCE course Body Fluid Differential Tutorial. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Normal Lymphocytes

This image demonstrates the normal range of variation for lymphocytes on a cytospin. The clover-leafing of the nuclei is a cytospin effect and is normal as long as the chromatin is mature, the nuclear:cytoplasmic ratio is normal, and overall size is normal.
Notice how the larger cells seem flattened and a bit more open in appearance than they would on a peripheral smear.