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The page below is a sample from the LabCE course Metabolic Syndrome. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Adipocyte production of angiotensinogen explains the frequent occurrence of hypertension in obesity and insulin resistance. Adipose tissue and liver cells produce angiotensinogen, a precursor of angiotensin II. Most angiotensinogen is from liver synthesis but increased levels in obesity are likely from increased adipocyte synthesis. Besides increasing blood pressure, angiotensin II may stimulate adipose cell formation and thus increase adipose mass.