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The page below is a sample from the LabCE course Red Blood Cell (RBC) Morphology. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Hemoglobin Concentration

The amount of central pallor is related to the hemoglobin concentration in the red blood cells (RBCs). When viewing normal mature RBCs on a Wright-stained smear, the central area (one-third of the cell) is pale, while pink- or buff-colored hemoglobin is visible in the outer two-thirds of the cell. The mean corpuscular hemoglobin concentration(MCHC) is an indice that represents the average concentration of hemoglobin in a deciliter (dL) of erythrocytes. A normal MCHC is approximately 32-36 g/dL.