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The page below is a sample from the LabCE course Red Blood Cell (RBC) Morphology. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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The term stomatocyte is derived from the Greek term stoma, meaning mouth. Stomatocytes have elongated or slit-like central pallors, which may be curved, giving the central pallor an appearance of a smiling mouth. The occasional stomatocyte seen in normal smears is the result of a slight pH change in the environment, similar to the in vitro changes that cause cells to assume the echinocyte shape. Two stomatocytes are indicated by arrows on this slide.