Clinical Relevance of D Phenotypes

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Clinical Relevance of D Phenotypes

Clinically relevant information on D phenotypes can be summarized in Table 3.
Table 3. Clinical Relevance of D Phenotypes.
D phenotypeD antigen expressionRh(D) typingProduce anti-DRBCs to transfuseRhIG recommended**
D+Normal DAT No D+ or D- No
Weak DNormal but weak IAT NoD+ or D- No
Partial DAltered DAT* & IAT Yes D- Yes
Partial weak DAltered & variable DAT* & IAT Yes D- Yes
D-None IATYes D- Yes
*Depending on anti-D reagent used
**USA, UK, and parts of Canada