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The page below is a sample from the LabCE course Chronic Kidney Disease. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Measurement of Creatinine, continued

Enzymatic assay design for creatinine varies between manufacturers, but commonly employs the enzyme creatininase coupled with a chromogen that reacts with hydrogen peroxide to form a product that can be quantified (Clarke, 2016). Enzymatic assays tend to be less sensitive to interference than the Jaffe reaction; however, interferents still exist that can influence assay performance. For example, bilirubin or ascorbate may interfere due to their ability to react with hydrogen peroxide, artificially decreasing its concentration (as a reporter molecule in the reaction) after the assay has completed.
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