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The page below is a sample from the LabCE course Chronic Kidney Disease. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Demographic Effects on Creatinine Generation

Normal values for creatinine vary by age, gender, and ethnicity of the patient. Due to these factors, adjustments are made in equations to ensure that goals and thresholds are set equitably, allowing comparisons across the population. Without adjustment, over- or under-estimation of GFR when using creatinine as a biomarker can occur.
In general, the following are observed (Jin, 2008):
  • Larger patients have higher GFR than smaller patients
  • Older patients have lower GFR than younger patients
  • Men have higher GFR than women
  • Persons of African descent have higher GFR than those of European descent
Adjustments to estimating equations have been considered in Asian populations but are not supported in validation studies to date (Teo, 2018).