RBC variations in shape are listed in the tables below along with associated conditions. The morphological variations in red blood cell shape that are shown in Table 1 have clinical significance, even in low numbers and should be identified and reported regardless of the frequency of observation on the smear.
Includes these specific types of cells:
- Prekaratocyte (blister cell)
- Keratocyte(helmet cell, horn cell)
Evidence of mechanical damage to the red blood cells.
Disseminated intravascular coagulation (DIC), severe burns, septicemia, certain drugs, thrombotic thrombocytopenic purpura (TTP)
|Sickle cell (Drepanocyte)||Sickle cell anemia|
|Spherocyte||Hereditary spherocytosis, some hemolytic anemias|
|Teardrop (Dacrocyte)||Thalassemia, hemolytic anemia, myelofibrosis|
Other morphological variations in red blood cell shape have little significance when seen in very low numbers and are clinically relevant when their presence is more obvious. These variations in shape that are significant only if observed in large numbers on the smear are listed in Table 2.