Home Products Most Popular Contact
No items in your cart.
The page below is a sample from the LabCE course Chronic Kidney Disease. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Chronic Kidney Disease (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 132 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart


Creatinine is a byproduct produced from the metabolism of creatine in muscle. It's plasma concentration is relatively constant and it is freely filtered at the glomerulus.
Its concentration is inverse to the GFR, i.e., higher concentrations of plasma creatinine are present with lower GFR.
Creatinine is an imperfect biomarker; it exhibits great interindividual variability and is affected by numerous factors beyond kidney function, to include:
  • Muscle mass (more muscle, higher creatinine)
  • Diet (e.g., vegan or a diet high in animal meat)
  • Non-renal disease (e.g., sickle cell)
  • Medications (may alter secretion and/or resorption)
  • Some extrarenal clearance
Image courtesy of Wikimedia Commons