Home Products Most Popular Contact
No items in your cart.
The page below is a sample from the LabCE course Hematopoietic Stem Cell Transplantation. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Hematopoietic Stem Cell Transplantation (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 132 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

Hematopoietic Stem Cells (HSCs)

HSCs are rare cells that can be found in the bone marrow and peripheral blood of adults, fetal liver tissue, and umbilical cord blood. They represent from 0.05-0.5% of the cellularity of the normal bone marrow. HSCs are responsible for the production of all hematopoietic cells. They are also capable of self-renewal that results in identical daughter cells. Self-renewal maintains constant stem cell populations throughout a person’s life.
HSCs are not recognizable on the basis of their morphology. They are small, mononuclear cells that appear to be small lymphocytes. HSCs can be differentiated by cell separation techniques that target specific antigens. One of the most important of these is CD34, a glycoprotein found on HSCs, early progenitor cells, and vascular endothelial cells. Other markers and their role in hematopoiesis are shown in the table.
HSC Markers for Differentiation
MarkerRole in Hematopoiesis
CD34Adhesion to stroma in the bone marrow
Thy-1T-lymphocyte adhesion
CD49fCell adhesion
CD38Indicates absence of differentiation markers
Lin-T-lymphocyte adhesion
HLA-DRDetermine histocompatibility
TPO-RReceptor for thrombopoietin