Two-Dimensional Electrophoresis Advantages and Applications

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The page below is a sample from the LabCE course Electrophoresis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Two-Dimensional Electrophoresis Advantages and Applications

Because of the two separation processes, more information and separated solutes can be gained from a sample.
The use of two-dimensional electrophoresis is specialized, and most applications are in research fields. It is used to study families of proteins in the field of proteomics and protein content in different types of cells. It is also used extensively in genetics to study disease differences, gene mutations, and bacterial DNA. To find ways to detect malignancies earlier, two-dimensional electrophoresis is also used to study tumor cells.