Because of the two separation processes, more information and separated solutes can be gained from a sample.
Two-dimensional electrophoresis is specialized, and most applications are in research fields. It is used to study families of proteins in proteomics and protein content in different types of cells. Genetics also uses it extensively to study disease differences, gene mutations, and bacterial DNA. Two-dimensional electrophoresis is also used to study tumor cells to find ways to detect malignancies earlier.