Home Products Most Popular Contact
No items in your cart.
The page below is a sample from the LabCE course Alpha Thalassemia. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Alpha Thalassemia (online CE course) »
This version of the course is no longer available.

Alpha Thalassemia Intermedia

Alpha thalassemia intermedia (Hemoglobin H Disease) results from a deletion of three out of four alpha chain gene loci. Infants born with alpha thalassemia intermedia appear normal at birth but often develop anemia and splenomegaly by the end of their first year. Development and life expectancy are usually normal, but some affected individuals may require splenectomy and transfusion therapy.

Hepatomegaly is not a common finding and there may be some association with mental retardation. Due to the hemolytic nature of this anemia, there may be an increase in respiratory infections, leg ulcers and gallstones. Skeletal changes are not commonly seen in hemoglobin H disease.

Any ethnic group can have occurrences of hemoglobin H disease; but it is most often seen in Southeast Asia, the Middle East and the Mediterranean islands.