Prevalence of HFE Mutations

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 175 CE courses, most popular
$109Add to cart
Pick Your Courses
Up to 8 CE hours
$55Add to cart
Individual course$25Add to cart
Need multiple seats for your university or lab? Get a quote
The page below is a sample from the LabCE course Hereditary Hemochromatosis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Hereditary Hemochromatosis (online CE course)
Prevalence of HFE Mutations

The C282Y mutation is common in the Caucasian population, especially in people of northern European descent. Approximately 10% of Caucasian Americans are heterozygous carriers of a single C282Y mutation.11 A greater percentage are carriers of the H63D mutation, but this mutation is much less clinically significant.
HH appears most prevalent among people of Celtic descent in the Northern British Isles--Scotland, Ireland, and Great Britain. Persons of Celtic descent in the United States, Australia, and France also have a relatively high incidence of HH. Approximately 1 out of 250 individuals in the United States are homozygous for the C282Y mutation, although the number with a clinical diagnosis of HH is lower. The prevalence of HFE mutations in African-Americans and Hispanic-Americans is low.