Heparin Neutralization

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The page below is a sample from the LabCE course Laboratory Evaluation of the Lupus Anticoagulant found in Antiphospholipid Syndrome (APS). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Laboratory Evaluation of the Lupus Anticoagulant found in Antiphospholipid Syndrome (APS) (online CE course)
Heparin Neutralization

Patients who present with a LA are prone to thrombosis and may be treated with heparin. These patients will also have a prolonged baseline aPTT due to the nature of the LA. In order to determine appropriate clotting times, it is important to be able to neutralize the presence of heparin. If a sample is contaminated with heparin, it is possible to neutralize the heparin by adding heparinase. This enzyme degrades unfractionated and low molecular weight heparin by cleaving its pentasaccharide sequence at multiple sites. The most important being antithrombin binding site which is required for heparin anticoagulation. This treatment can neutralize up to 2 units/mL of heparin.