Bleeding Complications in Patients with SLE

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The page below is a sample from the LabCE course Laboratory Evaluation of the Lupus Anticoagulant found in Antiphospholipid Syndrome (APS). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Laboratory Evaluation of the Lupus Anticoagulant found in Antiphospholipid Syndrome (APS) (online CE course)
Bleeding Complications in Patients with SLE

Bleeding, while rare in SLE, can occur under the following conditions:
  • Thrombocytopenia, which is found in up to about 20-25% of LA patients
  • A functional platelet disorder, possibly because of medications, in particular, due to anticoagulant/antiplatelet drugs
  • Obstetrical complications can result in incomplete abortions causing patients to have hemorrhagic events
A very rare event is lupus anticoagulant-hypoprothrombinemia syndrome (LAHS). This is caused by an acquired factor II deficiency, produced by anti-prothrombin antibodies, and lupus anticoagulant. Clinically, patients will present with a bleed and prolonged screening tests that do not correct with a mixing study. Factor II levels can range from between <1% to 25%.