Home Products Most Popular Contact
No items in your cart.
The page below is a sample from the LabCE course Case Studies in Pediatric Hematology. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Case Studies in Pediatric Hematology (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 132 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

Comparing Iron Studies in Iron Deficiency Anemia versus Anemia of Chronic Disease

This slide will compare iron study results in the anemias of iron deficiency and chronic disease/chronic inflammation.
Expected laboratory findings in iron deficiency anemia
  • Serum iron: Decreased
  • Serum ferritin: Decreased as iron stores are drained
  • Total iron binding capacity (TIBC): Increased, as more binding sites are open on the transferrin molecule secondary to iron deficiency
  • Prussian blue stain: No stainable bone marrow iron seen
  • Erythrocyte/zinc protoporphyrin: Increased - NOTE: This is one of the EARLIEST indicators of iron deficiency.
  • Typically, microcytic and hypochromic
Expected laboratory findings in anemia of chronic disease/chronic inflammation
Anemia of chronic disease/chronic inflammation is an anemia found in a number of chronic conditions, such as chronic kidney disease, chronic inflammatory conditions, and diabetes mellitus. The protein hepcidin is responsible for decreased absorption of iron from the diet. In addition, hepcidin also traps iron in macrophages, increasing the stored form of iron (ferritin).
  • Serum iron: Decreased, as hepcidin decreases iron absorption from the gastrointestinal (GI) tract
  • Serum ferritin: Increased, as hepcidin traps iron in macrophages
  • TIBC: Decreased, as more fewer sites are open on the transferrin molecule due to hepcidin trapping iron
  • Typically, normochromic and normocytic