Course Outline
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- Introduction to Red Blood Cell Morphology
- Normal Red Blood Cell Morphology
- The Peripheral Smear: Reviewing Red Blood Cell Morphology
- Abnormal Red Blood Cell Morphology Review
- Red Cell Morphology Reference Tables
- Size Variations in Red Blood Cells
- Anisocytosis Reference Table
- Variations in Hemoglobin Content
- Shape Variations in Red Blood Cells
- Poikilocytosis Review Table
- Abnormal Red Blood Cell Distribution
- Red Blood Cell Inclusions
- Red Blood Cell Inclusions and Associated Conditions
- Case Studies in Red Blood Cell Nonneoplastic Conditions
- Introduction to Red Blood Cell Nonneoplastic Conditions Case Studies
- Hemolytic Conditions with Spherocytosis
- Hemolytic conditions with spherocytosis: Case Study OneA 12-year-old child presents with jaundice and scleral icterus. The image to the right captures...
- Hemolytic conditions with spherocytosis: Case Study One, continued:Which hematologic condition could be associated with the findings shown in this ima...
- Hemolytic conditions with spherocytosis: Case Study Two A known case of hemolytic disease of the newborn (HDN) is presented in the image on the right....
- Hemolytic conditions with spherocytosis: Case Study ThreeA 49-year-old male with pneumonia was treated with high-dose intravenous penicillin. He becam...
- Macrocytosis-Associated Conditions
- Macrocytosis-associated conditions: Case Study One A complete blood count (CBC) was ordered for a patient recently admitted to the emergency departmen...
- Macrocytosis-associated conditions: Case Study TwoA patient has an elevated MCV on the automated CBC and a peripheral blood smear is reviewed. A repre...
- Intracellular RBC Inclusions
- Intracellular RBC inclusions: Case Study OneA twenty-five-year-old asplenic male with disseminated lymphoma is admitted to the hospital. A CBC is orde...
- Intracellular RBC inclusions: A toddler is being treated for lead poisoning. You observe the inclusions indicated by the arrows in many RBCs on the pe...
- A 66-year-old man has been diagnosed with sideroblastic anemia. The inclusions indicated by the arrows in the image were seen in many of the RBCs on h...
- A ten-year-old boy came to a physician's attention because of recent jaundice and icteric sclerae after taking the medication Primaquine. The immediat...
- Dimorphic Red Blood Cell Populations
- A blood smear represented by the photograph was submitted for hematologic review. Based on the erythrocyte morphology and the accompanying histogram, ...
- Target cells and Sickle Cells
- Hemoglobin E (HbE) and HbE/Beta Thalassemia
- Case Study A five-month-old Asian child is brought to the pediatrician by her mother who is concerned because the child is not eating well. Upon exami...
- A CBC and reticulocyte count are ordered on a 10-year-old African-American male who was brought to the emergency department with rapid, shallow breath...
- Sickle cells along with target cells, as shown in this image, confirm a diagnosis of sickle cell disease (HbSS).
- Schistocytes, Bite Cells, and Teardrop Cells
- Case Study A patient is diagnosed with disseminated intravascular coagulation (DIC) based on clinical findings and laboratory results that include dec...
- The top image on the right represents a Wright-stained microscopic field from a peripheral blood smear. The bottom image represents a microscopic fiel...
- The cells indicated by the arrows provide a clue to the diagnosis of chronic idiopathic myelofibrosis (primary myelofibrosis). What is the identity of...
- A 5-year-old girl was brought to the emergency department with bloody diarrhea and severe abdominal pain. A complete blood count produced these result...
- Ovalocytes, Elliptocytes and Stomatocytes
- Ovalocytes/Elliptocytes
- Stomatocytes
- Case StudyA 13-year-old healthy male presents to his physician for a sports physical. A complete blood count (CBC) is ordered. The automated count tri...
- Multiple Erythrocyte Abnormalities
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Clinical laboratory science students, and medical technologists and technicians seeking review, cross training, or continuing education opportunities. It is also appropriate for medical students and pathology residents.
Author information: C. William Reiquam, MD (1923-2015) was a clinical professor of pathology in the School of Medicine, University of Colorado. One of his areas of expertise was hematology.
Author information: Until his recent passing, Elmer W.Koneman M.D. was Professor Emeritus, Department of Pathology, University of Colorado School of Medicine. Dr. Koneman was a Board Certified Pathologist, former full Professor of Pathology University of Colorado School of Medicine. He was the author of numerous journal articles and books.
Reviewer information: Rory Huschka, M.Ed., MT(ASCP) is a Program Director at MediaLab Inc. He holds a BS degree from North Dakota State University in Medical Technology and an MS degree in Educational Leadership. He is a former Program Director for both MLT and MLS programs. Rory continues to teach as an adjunct professor for various colleges and universities.
