Pharmacology for the Clinical Chemist: Therapeutic Drug Monitoring and Pharmacogenomics (Online CE Course)

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1.5 hour(s) Approved through 8/31/2024

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Clinical Chemistry/UA/Toxicology): 1.5 hour(s) Approved through 8/31/2024

Objectives

• Define therapeutic drug monitoring (TDM) and explain the rationale for this testing.
• Explain the concept of elimination half-life.
• List the criteria and attributes of commonly monitored drugs.
• Discuss three methods that are used for the measurement of therapeutic drugs in serum.
• Define pharmacogenomics, polymorphism and CYP450; explain what is meant by "individualized medicine" or "personalized medicine."
• Explain the usefulness of CYP450 testing as well as its shortcomings.
• List the four classifications of metabolizers and explain the clinical relevance of each.

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Course Outline

• TDM
• Introduction
• Therapeutic Drug Monitoring Definition
• Pharmacogenomics Definition
• Basic Pharmacokinetics
• Drug Concentration Over Time
• Drug Metabolism
• Drug Elimination
• Half-Life
• Bioavailability
• Protein Binding
• Protein Availability and Drug Dosing
• Other Factors Affecting Drug Absorption and Distribution
• Given what you have learned thus far, which of the following statements below is true?
• Steady State
• Steady State Example
• Sampling
• Peak and Trough Sampling Times
• Why TDM?
• Why TDM?
• Unexpected Concentrations
• A physician needs to prescribe a drug to a patient but the drug has a narrow therapeutic window. He is concerned about possible toxic effects. To asse...
• TDM For All Drugs?
• When is TDM Not Useful?
• Alternatives to TDM
• Examples of Drugs That are Monitored by TDM
• TDM for Antibiotics
• TDM for Anticonvulsants
• TDM for Immunosuppressants
• TDM for Cardiac Medications
• TDM for Theophylline
• Albuterol is a fast-acting bronchodilator used acutely during asthma attacks. Which of the reasons below would best explain why TDM for albuterol is n...
• Laboratory Methods
• Chemiluminescence
• Pharmacogenomics
• Personalized Medicine
• Polymorphism and CYP450
• CYP450s
• CYP2D6
• Metabolizers
• Enzyme Abnormalities and Drugs
• Clinical Utility
• Warfarin Metabolism
• Warfarin Metabolism, continued
• A person who is classified as an ultrarapid metabolizer (UM) would need __________ of a drug metabolized by that enzyme.
• CYP450 Induction and Inhibition
• CYP450 Induction and Inhibition, continued
• A patient is taking cimetidine for a stomach ulcer. This drug inhibits CYP2D6. The patient is now prescribed amphetamine for narcolepsy. Amphetamine i...
• Genotype versus Phenotype
• Genotype versus Phenotype, continued
• TDM and PGx
• The Bottom Line
• The Bottom Line, continued
• References
• References

Additional Information

Level of instruction: Intermediate

Intended Audience: Clinical laboratory technologists and technicians as well as other health care personnel who are responsible for prescribing and administering therapeutic medications.